Platform technology
Developing Targeted Therapies With no Compromise
Sagitta© Bir and Sagitta© Dui are discovered to address the challenge of having an optimum therapeutic index for cancer treatment with biodegradable conjugation platforms that reinforce ideal performances in terms of efficacy, PK and manufacturability.
Sagitta©
Developing Targeted Therapies With no Compromise
Sagitta© Bir and Sagitta© Dui are discovered to address the challenge of having an optimum therapeutic index for cancer treatment with biodegradable conjugation platforms that reinforce ideal performances in terms of efficacy, PK and manufacturability.
The lead candidate: RS-0139
The lead candidate: RS-0337
The lead candidate: RS-0139
Upon contact with water, Sagitta© Bir backbone wraps around the payload, ensuring formation of a water soluble nanocarrier.
The lead candidate: RS-0337
Upon contact with water, Sagitta© Dui forms a micellar nanoparticle, encapsulating the second payload.
Therapeutic Index
The dual drug loading capacity of Sagitta© yields to a synergistic therapeutic effect. Sagitta© platform is compatible with a wide range of targeting ligands or mAbs as well as a diverse choice of drugs – ensuring highest efficacy and specificity.
Pharmacokinetics
Sagitta© platform significantly prolongs the circulation time compared to native API. The improvement in half-life translated across species and therefore poses predictable promise for later clinical stages.
Manufacturing
HIGHER
THERAPEUTIC INDEX
The dual drug loading capacity of Sagitta© yields to a synergistic therapeutic effect. Sagitta© platform is compatible with a wide range of targeting ligands or mAbs as well as a diverse choice of drugs – ensuring highest efficacy and specificity.
IMPROVED
PHARMACOKINETICS
Sagitta© platform significantly prolongs the circulation time compared to native API. The improvement in half-life translated across species and therefore poses predictable promise for later clinical stages.
STRAIGHT-FORWARD
MANUFACTURING
We manufacture our products at our own GMP certificated production facility for clinical batch lyophilized oncology drugs.
